The fire broke out at 23 Baxter Street in the city's First Ward on Thursday morning.
During an investigation, police say a possible meth lab was found in the apartment where the fire started.
Christopher Osborne, 23, and Ashley Ottaviani, 23, who both lived at the apartment, have been charged with making meth and drug possession.
The police are continuing to look into the case.
If you have any information, you're asked to call Binghamton Detectives at 772-7080.
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