It occurred at about 9:10 p.m. in the area of North and Mather streets.
Police say a group of men were fighting when a light-colored hatchback pulled up and then shots were fired.
The driver is described as a heavy set Hispanic man with his hair pulled back into a ponytail.
Police say after the shooting, 30-year-old Anthony Carter of Binghamton went to an emergency room after being shot in the leg.
Shortly after, 32-year-old James High of Binghamton walked into another emergency room for an injury during the fight.
Anyone with information is asked to call Binghamton Police Detectives at 772-7080.
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